non-protective versus protective lung ventilation.decreased lung injury development (risk ratio, 0.33 95% CI, 0.23 to 0.47 I2, 0% NNT = 11).Serpa Neto et al (2012) performed a meta-analysis of 20 studies (n=2822) that showed patients receiving lower tidal volumes had: avoiding excessive plateau pressures may be as important as low tidal volumes.note that the tidal volume could be adjusted so long as the plateau pressure was This is described in detail in ARDSnet Ventilation Strategy.
clear evidence for benefit in ARDS in animals and humans.hypercapnia may also have directly beneficial effects in ARDS.
biotrauma (release of inflammatory mediators).barotrauma (alveolar rupture and pneumothorax).volutrauma (hyperinflation and shearing injury).low tidal volume ventilation reduces ventilator-associated lung injury (VALI).Note: PBW in men is calculated as 50 (45 in women) + 0.91 (Height cm −152.4).